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ea0003p158 | Genetics | BES2002

Lack of association between polymorphic markers within 11b-hydroxysteroid dehydrogenase type 1 gene (HSD11B1) and obesity

Draper N , Echwald S , Sorensen T , Astrup A , Lavery G , Chalder S , Hewison M , Pedersen O , Stewart P

11beta-hydroxysteroid dehydrogenase regulates glucocorticoid action, by interconverting cortisone (E) to cortisol (F). The Type 1 isozyme (11betaHSD1) is an oxoreductase expressed in adipose tissue, where it may play a role in the pathogenesis of visceral obesity.We have characterised two polymorphic (CA)n microsatellite markers within intron 4 of the HSD11B1 gene, termed (CA)15 and (CA)19. In an earlier study evaluating a 'normal' population (MONICA co...

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ea0029oc11.2 | Thyroid Clinical 2 | ICEECE2012

Subclinical thyroid disease and risk of new-onset atrial fibrillation

Selmer C. , Olesen J. , Lindhardsen J. , Olsen A. , Madsen J. , Schmidt U. , Faber J. , Hansen P. , Pedersen O. , Hansen M. , Torp-Pedersen C. , Gislason G.

Background: It is still uncertain if subclinical thyroid disease or high-normal thyroid function are risk-factors for atrial fibrillation (AF).Objectives: To examine the risk of AF in relation to thyroid function.Methods: Patients consulting their general practitioner from 20002009 in Copenhagen, Denmark, who underwent thyroid blood tests, were identified by individual-level linkage of nationwide registries. Patie...

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Endocrine Abstracts

Lack of association between polymorphic markers within 11b-hydroxysteroid dehydrogenase type 1 gene (HSD11B1) and obesity

Subclinical thyroid disease and risk of new-onset atrial fibrillation

BiosciAbstracts